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Registro Completo |
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Biblioteca(s): |
Embrapa Agroenergia. |
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Data corrente: |
15/03/2019 |
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Data da última atualização: |
18/11/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MESQUITA, L. M. de S.; RODRIGUES, C. F. B.; ROCHA, C. Q. da; BIANCHIM, M. S.; RODRIGUES, C. M.; OLIVEIRA, V. de; GAETA, H. H.; BELCHOR, M. N.; TOYAMA. M. H.; VILEGAS, W. |
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Afiliação: |
Leonardo Mendes de Souza Mesquita; Caroline Fabri Bittencourt Rodrigues; Claudia Quintino da Rocha; Mayara Silveira Bianchim; CLENILSON MARTINS RODRIGUES, CNPAE; Vanda Maria de Oliveira; Henrique Hessel Gaeta; Mariana Novo Belchor; Marcos Hikari Toyama; Wagner Vilegas. |
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Título: |
LC-ESI-IT-MS/MS and MALDI-TOF approach: identification of natural polymers from rhizophora mangle barks and determination of their analgesic and anti-inflammatory properties. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Natural Products and Bioprospecting, v. 9, p. 23-34, 2019. |
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Idioma: |
Inglês |
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Conteúdo: |
We recognize the chemical composition of the acetonic extract of Rhizophora mangle barks (AERM) using mass spectrometry analysis [liquid chromatography (LC)?ESI?IT-MS/MS and matrix-assisted laser desorption/ionization-time of flight-MS (MALDI-TOF)]. Analgesic activity was evaluated by formalin and tail-flick experimental assays. Anti-inflammatory activity was performed by paw edema test induced by carrageenan and 48/80 compounds. The first series of experiments involved [LC]?FIA?IT-MS/MS with 11 separated catechins derivatives until degree of polymerization 3 (DP3). The spectra obtained by MALDI-TOF analysis of the AERM presented two homologous series: one based on polymers of m/z 288 Da increments (up to DP12) and another series based on polymers of m/z [288 ? 162] Da increments (up to DP11). In addition to these series of flavan-3-ol, each DP had a subset of masses with a variation of - 16 Da (homologous series of afzelechins?m/z 873?3465 Da) and ? 16 Da (homologous series of gallocatechins?m/z 905?3497 Da). A similar pattern with homologous series of gallocatechins and afzelechins could also be observed for a fifth and a sixth monohexoside series: glucogallocatechins (m/z 779?3371) and glucoafzelechins (m/z 747?3339). The intraperitoneal administration of different doses of AERM (50, 150 and 300 lg mL-1) have a morphine-like effect and intense anti-inflammatory activity. |
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Palavras-Chave: |
Anti-inflammatory; Catechins; Mangroves; Morphine-like effect. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/194310/1/CLENILSON-041Natural-Products-and-Bioprospecting.pdf
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Marc: |
LEADER 02289naa a2200277 a 4500
001 2107120
005 2019-11-18
008 2019 bl uuuu u00u1 u #d
100 1 $aMESQUITA, L. M. de S.
245 $aLC-ESI-IT-MS/MS and MALDI-TOF approach$bidentification of natural polymers from rhizophora mangle barks and determination of their analgesic and anti-inflammatory properties.$h[electronic resource]
260 $c2019
520 $aWe recognize the chemical composition of the acetonic extract of Rhizophora mangle barks (AERM) using mass spectrometry analysis [liquid chromatography (LC)?ESI?IT-MS/MS and matrix-assisted laser desorption/ionization-time of flight-MS (MALDI-TOF)]. Analgesic activity was evaluated by formalin and tail-flick experimental assays. Anti-inflammatory activity was performed by paw edema test induced by carrageenan and 48/80 compounds. The first series of experiments involved [LC]?FIA?IT-MS/MS with 11 separated catechins derivatives until degree of polymerization 3 (DP3). The spectra obtained by MALDI-TOF analysis of the AERM presented two homologous series: one based on polymers of m/z 288 Da increments (up to DP12) and another series based on polymers of m/z [288 ? 162] Da increments (up to DP11). In addition to these series of flavan-3-ol, each DP had a subset of masses with a variation of - 16 Da (homologous series of afzelechins?m/z 873?3465 Da) and ? 16 Da (homologous series of gallocatechins?m/z 905?3497 Da). A similar pattern with homologous series of gallocatechins and afzelechins could also be observed for a fifth and a sixth monohexoside series: glucogallocatechins (m/z 779?3371) and glucoafzelechins (m/z 747?3339). The intraperitoneal administration of different doses of AERM (50, 150 and 300 lg mL-1) have a morphine-like effect and intense anti-inflammatory activity.
653 $aAnti-inflammatory
653 $aCatechins
653 $aMangroves
653 $aMorphine-like effect
700 1 $aRODRIGUES, C. F. B.
700 1 $aROCHA, C. Q. da
700 1 $aBIANCHIM, M. S.
700 1 $aRODRIGUES, C. M.
700 1 $aOLIVEIRA, V. de
700 1 $aGAETA, H. H.
700 1 $aBELCHOR, M. N.
700 1 $aTOYAMA. M. H.
700 1 $aVILEGAS, W.
773 $tNatural Products and Bioprospecting$gv. 9, p. 23-34, 2019.
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Registro original: |
Embrapa Agroenergia (CNPAE) |
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| Registros recuperados : 9 | |
| 1. |  | MENDES, L.; QUINTINO, C.; RODRIGUES, C. M.; OLIVEIRA, V.; VILEGAS, W. Phytochemical analysis from Rhizophora mangle barks: FIA-ESI-IT-MS/MS and MALDI-TOF approach. In: ITALO LATIN AMERICAN CONGRESS OF ETNOMEDICINA, 26.; COLOMBIAN CONGRESS OF CHROMATOGRAPHY, 9., 2017, Cartagena das Indias. [Anais ...]. [S.l.]: SILAE, 2017. Não paginado.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroenergia. |
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| 3. | | HIRUMA-LIMA, C. A.; RODRIGUES, C. M.; SANTOS, L. C. DOS; SILVA, V. C. DA; VILEGAS, W. Flavonoides. In: FURTADO, N. A. J. C.; VENEZIANI, R. C. S.; AMBRÓSIO, S. R. (Ed.). Farmacognosia. Rio de Janeiro : Atheneu, 2017. p. 387-406. (Coleção Farmácia, 7).| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Agroenergia. |
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| 4. | | FANTATTO, R. R.; CHAGAS, A. C. de S.; ALEMAN GAINZA, Y.; POLITI, F. A. S.; MESQUITA, L. M. DE S.; VILEGAS, W.; BIZZO, H. R.; MONTANARI JUNIOR, I.; PIETRO, R. C. L. R. Acaricidal and anthelmintic action of ethanolic extract and essential oil of Achyrocline satureioides. Experimental Parasitology, v236?237, may-june 2022, 108252. 8 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Agroindústria de Alimentos; Embrapa Pecuária Sudeste. |
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| 5. | | NISHIJIMA, C. M.; DELELLA, F. K.; RODRIGUES, C. M.; RINALDO, D.; LOPES-FERREIRA, M. V. dos Anjos; ROCHA, L. R. M. da; VILEGAS, W.; FELISBINO, S. L.; HIRUMA-LIMA, C. A. The anti-inflammatory effects of the methanolic extract and fractions from Davilla elliptica St Hil (Dilleniaceae) on Bothrops jararaca envenomation. International Journal of Molecular Sciences, v. 16, n. 6, 2015| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Agroenergia. |
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| 6. | | MESQUITA, L. M. de S.; RODRIGUES, C. F. B.; ROCHA, C. Q. da; BIANCHIM, M. S.; RODRIGUES, C. M.; OLIVEIRA, V. de; GAETA, H. H.; BELCHOR, M. N.; TOYAMA. M. H.; VILEGAS, W. LC-ESI-IT-MS/MS and MALDI-TOF approach: identification of natural polymers from rhizophora mangle barks and determination of their analgesic and anti-inflammatory properties. Natural Products and Bioprospecting, v. 9, p. 23-34, 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 3 |
| Biblioteca(s): Embrapa Agroenergia. |
|  |
| 7. | | SANNOMIYA, M.; RODRIGUES, C. M.; OLIVEIRA, G. C. A.; CARVALHO, J. C. S.; COSTA, L. S. DA; SPADARI, C. DE C.; FERREIRA, M. J. P.; VILEGAS, W.; ISHIDA, K. Galloylquinic acid derivatives from Byrsonima fagifolia leaf extract and potential antifungal activity. Journal of Ethnopharmacology, n. 297, e115534, 2022. 5 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agroenergia. |
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| 8. | | RODRIGUES, C. M.; BENTO, C. C.; MORAES, C. B.; GOMES, C.; IOSHINO, R. S.; FREITAS-JUNIOR, L. H.; SPADARI, C. de C.; ISHIDA, K.; VILEGAS, W.; CARVALHO, J. C. S.; FERREIRA, M. J. P.; CARBONE, V.; PIACENTE, S.; ANGELO, R. M. de; HONORIO, K. M.; SANNOMIYA, M. A potential antiviral against COVID-19 obtained from Byrsonima coccolobifolia leaves extract. Fitoterapia, v. 173, Mar. 2024.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 4 |
| Biblioteca(s): Embrapa Agroenergia. |
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| 9. | | SANTOS, R. de C. dos; BONAMINA, F.; PÉRICO, L. L.; RODRIGUES, V. P.; ZANATTA, A. C.; RODRIGUES, C. M.; SANNOMIYA, M.; RAMOS. M. A. dos S.; BONIFÁCIO, B. V.; BAUAB, T. M.; TAMASHIRO, J.; ROCHA, L. R. M. da; VILEGAS, W.; HIRUMA-LIMA, C. A. Byrsonima intermedia A. Juss partitions promote gastroprotection against peptic ulcers and improve healing through antioxidant and antiinflammatory activities. Biomedicine & Pharmacotherapy, v. 111, p. 1112-1123, 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Agroenergia. |
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| Registros recuperados : 9 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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